The promises and challenges of patient-derived tumor...

The promises and challenges of patient-derived tumor organoids in drug development and precision oncology.

Abstract In the era of precision medicine, cancer researchers and oncologists are...

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Young Investigators Exploit Patient Samples for Cancer...

Young Investigators Exploit Patient Samples for Cancer Studies

Young investigators at Dana-Farber are working to understand why tumors may be...

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Curbing cancer’s addiction to treat it

Curbing cancer’s addiction to treat it

Just like us, cancer has things it can’t live without. They’re not...

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Wnt Signaling in 3D: Recent Advances in...

Wnt Signaling in 3D: Recent Advances in the Applications of Intestinal Organoids.

Abstract Intestinal organoids grown from adult stem cells have emerged as prototype...

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From genomics to functions: preclinical mouse models...

From genomics to functions: preclinical mouse models for understanding oncogenic pathways in prostate cancer.

Abstract Next-generation sequencing has revealed numerous genomic alterations that induce aberrant signaling...

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The kinase activity of ERBB3 contributes to...

The kinase activity of ERBB3 contributes to intestinal organoids growth and intestinal tumorigenesis.

Abstract ERBB3, a member of the epidermal growth factor receptor (EGFR) family,...

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Patient-derived tumor models of esophageal cancer.

Patient-derived tumor models of esophageal cancer.

Abstract Tumor models are powerful tools to plan preclinical therapeutic strategies that...

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Patient-Derived Head and Neck Cancer Organoids Recapitulate...

Patient-Derived Head and Neck Cancer Organoids Recapitulate EGFR Expression Levels of Respective Tissues and Are Responsive to EGFR-Targeted Photodynamic Therapy.

Abstract Patients diagnosed with head and neck squamous cell carcinoma (HNSCC) are...

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Organoid cultures as preclinical models of non-small...

Organoid cultures as preclinical models of non-small cell lung cancer.

Abstract PURPOSE: Non-small cell lung cancer (NSCLC) is the most common cause...

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