Patient-Derived In Vitro Models for Drug Discovery...

Patient-Derived In Vitro Models for Drug Discovery in Colorectal Carcinoma

Abstract Lack of relevant preclinical models that reliably recapitulate the complexity and...

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Recommended Guidelines for Developing, Qualifying, and Implementing...

Recommended Guidelines for Developing, Qualifying, and Implementing Complex In Vitro Models (CIVMs) for Drug Discovery

Abstract The pharmaceutical industry is continuing to face high research and development...

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Metabolic Profiling of Early and Late Recurrent...

Metabolic Profiling of Early and Late Recurrent Pancreatic Ductal Adenocarcinoma Using Patient-Derived Organoid Cultures

Abstract Pancreatic ductal adenocarcinoma (PDAC) is associated with high mortality and will...

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Organoids used to study ovarian cancer

Organoids used to study ovarian cancer

Mini versions of mouse reproductive organs have been used to investigate how...

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Assessing the Origin of High-Grade Serous Ovarian...

Assessing the Origin of High-Grade Serous Ovarian Cancer Using CRISPR-modification of Mouse Organoids

Abstract High-grade serous ovarian cancer (HG-SOC)-often referred to as a "silent killer"-is...

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Identifying Predictors of HPV-related Head and Neck...

Identifying Predictors of HPV-related Head and Neck Squamous Cell Carcinoma Progression and Survival Through Patient-Derived Models

Abstract Therapeutic innovation for human papilloma virus-related (HPV+) head and neck squamous...

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“Tissues in a Dish”: A Review of...

“Tissues in a Dish”: A Review of Organoids in Plastic Surgery

Abstract Organoids are in vitro miniaturized organ models-or, colloquially, "organs in a...

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Methodological aspects and pharmacological applications of three-dimensional...

Methodological aspects and pharmacological applications of three-dimensional cancer cell cultures and organoids.

Abstract Two-dimensional (2D) cell cultures, in which cells grow in flat layers...

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Novel methods for in vitro modeling of...

Novel methods for in vitro modeling of pancreatic cancer reveal important aspects for successful primary cell culture.

Abstract BACKGROUND: Pancreatic cancer remains a fatal disease. Experimental systems are needed...

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