Pooled In Vitro and In Vivo CRISPR-Cas9...

Pooled In Vitro and In Vivo CRISPR-Cas9 Screening Identifies Tumor Suppressors in Human Colon Organoids.

Abstract Colorectal cancer (CRC) is characterized by prominent genetic and phenotypic heterogeneity...

publicationsRead More>

Notch Signaling Mediates Differentiation in Barrett’s Esophagus...

Notch Signaling Mediates Differentiation in Barrett’s Esophagus and Promotes Progression to Adenocarcinoma.

Abstract BACKGROUND & AIMS: Studies are needed to determine the mechanism by...

publicationsRead More>

Paracrine orchestration of intestinal tumorigenesis by a...

Paracrine orchestration of intestinal tumorigenesis by a mesenchymal niche.

Abstract The initiation of an intestinal tumour is a probabilistic process that...

publicationsRead More>

Production of Human Pluripotent Stem Cell-Derived Hepatic...

Production of Human Pluripotent Stem Cell-Derived Hepatic Cell Lineages and Liver Organoids: Current Status and Potential Applications.

Abstract Liver disease is one of the leading causes of death worldwide,...

publicationsRead More>

Progress in the application of organoids to...

Progress in the application of organoids to breast cancer research.

Abstract Breast cancer is the most common cancer diagnosed in women. Breast...

publicationsRead More>

An organoid biobank for childhood kidney cancers...

An organoid biobank for childhood kidney cancers that captures disease and tissue heterogeneity.

Abstract Kidney tumours are among the most common solid tumours in children,...

publicationsRead More>

Fabrication of Dentin-Pulp-Like Organoids Using Dental-Pulp Stem...

Fabrication of Dentin-Pulp-Like Organoids Using Dental-Pulp Stem Cells.

Abstract We developed a novel dentin-pulp-like organoid. It has both stem-cell and...

publicationsRead More>

Establishment of patient-derived three-dimensional organoid culture in...

Establishment of patient-derived three-dimensional organoid culture in renal cell carcinoma.

Abstract Purpose: Renal cell carcinoma is a heterogeneous kidney cancer, and over...

publicationsRead More>

Prioritizing Gene Cascading Paths to Model Colorectal...

Prioritizing Gene Cascading Paths to Model Colorectal Cancer Through Engineered Organoids.

Abstract Engineered organoids by sequential introduction of key mutations could help modeling...

publicationsRead More>