Impacting pancreatic cancer therapy in heterotypic in...

Impacting pancreatic cancer therapy in heterotypic in vitro organoids and in vivo tumors with specificity-tuned, NIR-activable photoimmunonanoconjugates: towards conquering desmoplasia?

Abstract Despite untiring efforts to develop therapies for pancreatic ductal adenocarcinoma (PDAC),...

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Metastatic seeding of human colon cancer cell...

Metastatic seeding of human colon cancer cell clusters expressing the hybrid epithelial/mesenchymal state.

Abstract Emerging evidence supports the theory that tumor cell clusters efficiently metastasize...

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Identification of Resistance Pathways Specific to Malignancy...

Identification of Resistance Pathways Specific to Malignancy Using Organoid Models of Pancreatic Cancer.

Abstract PURPOSE: KRAS is mutated in the majority of pancreatic ductal adenocarcinoma....

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Patient-derived lung cancer organoids as in vitro...

Patient-derived lung cancer organoids as in vitro cancer models for therapeutic screening.

Abstract Lung cancer shows substantial genetic and phenotypic heterogeneity across individuals, driving...

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Characterization of in vitro Mrp2 transporter model...

Characterization of in vitro Mrp2 transporter model based on intestinal organoids.

Abstract: Multidrug resistance associated protein 2 (MRP2) is an important efflux transporter...

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Immunoevolution of mouse pancreatic organoid isografts from...

Immunoevolution of mouse pancreatic organoid isografts from preinvasive to metastatic disease.

Pancreatic ductal adenocarcinoma (PDA) has a highly immunosuppressive microenvironment, which is contributed...

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Paracrine Crosstalk between Fibroblasts and ER+ Breast...

Paracrine Crosstalk between Fibroblasts and ER+ Breast Cancer Cells Creates an IL1β-Enriched Niche that Promotes Tumor Growth.

Abstract Breast cancer-induced activated fibroblasts support tumor progression. However, the role of...

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Allometric Scaling of physiologically-relevant organoids.

Allometric Scaling of physiologically-relevant organoids.

Abstract The functional and structural resemblance of organoids to mammalian organs suggests...

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Adult and iPS-derived non-parenchymal cells regulate liver...

Adult and iPS-derived non-parenchymal cells regulate liver organoid development through differential modulation of Wnt and TGF-β.

Abstract BACKGROUND: Liver organoid technology holds great promises to be used in...

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