Organoid Research Group Publications

Methodological aspects and pharmacological applications of three-dimensional...

Methodological aspects and pharmacological applications of three-dimensional cancer cell cultures and organoids.

Abstract Two-dimensional (2D) cell cultures, in which cells grow in flat layers...

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Novel methods for in vitro modeling of...

Novel methods for in vitro modeling of pancreatic cancer reveal important aspects for successful primary cell culture.

Abstract BACKGROUND: Pancreatic cancer remains a fatal disease. Experimental systems are needed...

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Review Outlines Successes, Limitations of Personalized Medicine...

Review Outlines Successes, Limitations of Personalized Medicine in Oncology

The evolution of cancer treatment towards a precision-based approach has led to...

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Patient-derived tumor organoid predicts drugs response in...

Patient-derived tumor organoid predicts drugs response in glioblastoma: A step forward in personalized cancer therapy?

Abstract Despite significant medical advances, glioblastoma multiforme (GBM) remains a formidable therapeutic...

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Pooled In Vitro and In Vivo CRISPR-Cas9...

Pooled In Vitro and In Vivo CRISPR-Cas9 Screening Identifies Tumor Suppressors in Human Colon Organoids.

Abstract Colorectal cancer (CRC) is characterized by prominent genetic and phenotypic heterogeneity...

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Notch Signaling Mediates Differentiation in Barrett’s Esophagus...

Notch Signaling Mediates Differentiation in Barrett’s Esophagus and Promotes Progression to Adenocarcinoma.

Abstract BACKGROUND & AIMS: Studies are needed to determine the mechanism by...

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Paracrine orchestration of intestinal tumorigenesis by a...

Paracrine orchestration of intestinal tumorigenesis by a mesenchymal niche.

Abstract The initiation of an intestinal tumour is a probabilistic process that...

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Production of Human Pluripotent Stem Cell-Derived Hepatic...

Production of Human Pluripotent Stem Cell-Derived Hepatic Cell Lineages and Liver Organoids: Current Status and Potential Applications.

Abstract Liver disease is one of the leading causes of death worldwide,...

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Progress in the application of organoids to...

Progress in the application of organoids to breast cancer research.

Abstract Breast cancer is the most common cancer diagnosed in women. Breast...

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