Identification of Resistance Pathways Specific to Malignancy Using Organoid Models of Pancreatic Cancer.

Abstract PURPOSE: KRAS is mutated in the majority of pancreatic ductal adenocarcinoma. MAPK and PI3K-AKT are primary KRAS effector pathways, but combined MAPK and PI3K inhibition has not been demonstrated to be clinically effective to date. We explore the resistance mechanisms uniquely employed by malignant cells. EXPERIMENTAL DESIGN: We […]

View Original Source at Identification of Resistance Pathways Specific to Malignancy Using Organoid Models of Pancreatic Cancer.