Robust, Long-Term Culture of Endoderm-Derived Hepatic Organoids for Disease Modeling.

Abstract Organoid technologies have become a powerful emerging tool to model liver diseases, for drug screening, and for personalized treatments. These applications are, however, limited in their capacity to generate functional hepatocytes in a reproducible and efficient manner. Here, we generated and characterized the hepatic organoid (eHEPO) culture system […]

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