Recommended Guidelines for Developing, Qualifying, and Implementing...

Recommended Guidelines for Developing, Qualifying, and Implementing Complex In Vitro Models (CIVMs) for Drug Discovery

Abstract The pharmaceutical industry is continuing to face high research and development...

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Metabolic Profiling of Early and Late Recurrent...

Metabolic Profiling of Early and Late Recurrent Pancreatic Ductal Adenocarcinoma Using Patient-Derived Organoid Cultures

Abstract Pancreatic ductal adenocarcinoma (PDAC) is associated with high mortality and will...

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Assessing the Origin of High-Grade Serous Ovarian...

Assessing the Origin of High-Grade Serous Ovarian Cancer Using CRISPR-modification of Mouse Organoids

Abstract High-grade serous ovarian cancer (HG-SOC)-often referred to as a "silent killer"-is...

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Identifying Predictors of HPV-related Head and Neck...

Identifying Predictors of HPV-related Head and Neck Squamous Cell Carcinoma Progression and Survival Through Patient-Derived Models

Abstract Therapeutic innovation for human papilloma virus-related (HPV+) head and neck squamous...

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“Tissues in a Dish”: A Review of...

“Tissues in a Dish”: A Review of Organoids in Plastic Surgery

Abstract Organoids are in vitro miniaturized organ models-or, colloquially, "organs in a...

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Methodological aspects and pharmacological applications of three-dimensional...

Methodological aspects and pharmacological applications of three-dimensional cancer cell cultures and organoids.

Abstract Two-dimensional (2D) cell cultures, in which cells grow in flat layers...

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Novel methods for in vitro modeling of...

Novel methods for in vitro modeling of pancreatic cancer reveal important aspects for successful primary cell culture.

Abstract BACKGROUND: Pancreatic cancer remains a fatal disease. Experimental systems are needed...

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Review Outlines Successes, Limitations of Personalized Medicine...

Review Outlines Successes, Limitations of Personalized Medicine in Oncology

The evolution of cancer treatment towards a precision-based approach has led to...

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Patient-derived tumor organoid predicts drugs response in...

Patient-derived tumor organoid predicts drugs response in glioblastoma: A step forward in personalized cancer therapy?

Abstract Despite significant medical advances, glioblastoma multiforme (GBM) remains a formidable therapeutic...

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